Amaryl M 2/500mg Tabs 30’s is a combination of two antidiabetic medicines: Glimepiride 2mg and Metformin 500mg. Glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver. Therefore, it delays glucose absorption from intestines and increasing the body’s sensitivity to insulin.